Acetic Acid → HCID 14003461, compound

HRID 845336Notes

Reaction equation

HRID 845336 reaction equation
[NH2:1][CH:2]1[CH2:8][CH2:7][CH2:6][CH:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:4]([CH2:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[C:3]1=[O:23].O=[C:25]([CH2:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:26]([O:28][CH2:29][CH3:30])=[O:27].C(O)(=O)C>C(O)C>[C:19]([O:18][C:16]([CH2:15][N:4]1[CH:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:6][CH2:7][CH2:8][CH:2]([NH:1][CH:25]([C:26]([O:28][CH2:29][CH3:30])=[O:27])[CH2:31][CH2:32][C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[C:3]1=[O:23])=[O:17])([CH3:20])([CH3:22])[CH3:21]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 562087Ethyl alpha-oxobenzenebutanoateHCID 14003453HCID 14003453, compound

Product 1

HCID 14003461HCID 14003461, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3.8 g of the amine from Step D, 3.7 g ethyl 2-oxo-4-phenylbutyrate, and 0.68 ml acetic acid in 50 ml ethanol was hydrogenated and the isomers separated by chromatography on silica gel using 1:1 ethylacetate:hexane to afford 1-t-butoxycarbonylmethyl-3-(1-ethoxycarbonyl-3-phenylpropyl)amino-7-phenylperhydroazepin-2-one:

Workup

  1. customthe isomers separated by chromatography on silica gel using 1:1 ethylacetate

Sources & evidence

ORD record
ord-3ea9e784c5bc4e8aad1af06d50d6b76b
Source dataset
uspto-grants-1988_07
Patent number
US04757068

Reaction notes

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