HRID845370

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24648

Sulfuryl chloride

Cl2O2S

结构：CCCCOc1ccc(C(=O)CC(=O)Nc2cc(OC(=O)CCOC(=O)c3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)ccc2Cl)cc1

HCID86742264

未命名化合物

PRODUCTS

生成物

结构：CCCCOc1ccc(C(=O)C(Cl)C(=O)Nc2cc(OC(=O)CCOC(=O)c3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)ccc2Cl)cc1

HCID86742265

未命名化合物

收率 99%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

2 次

PROCEDURE

实验过程

Sulphuryl chloride (4.9 g, 36.2 mmole) in dichloromethane (10 ml) was slowly added to a solution of the 4 equivalent coupler from (f) (24.1 g, 36.2 mmole) in dichloromethane (140 ml). After stirring at room temperature for 21 hours, the volatiles were removed by rotary evaporation. The product was isolated as a yellow oil (25.1 g, 99%) and was used in the next reaction without further purification.

WORKUP

后处理

customthe volatiles were removed by rotary evaporation

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-35cc148ce80d4261bee75b277fbf1728
来源数据集: uspto-grants-1988_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04758501
来源说明: uspto-grants-1988_07

反应 SMILES

S(Cl)([Cl:4])(=O)=O.[C:6]([C:10]1[CH:11]=[C:12]([CH:45]=[C:46]([C:49]([CH3:52])([CH3:51])[CH3:50])[C:47]=1[OH:48])[C:13]([O:15][CH2:16][CH2:17][C:18]([O:20][C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([NH:28][C:29](=[O:44])[CH2:30][C:31]([C:33]2[CH:38]=[CH:37][C:36]([O:39][CH2:40][CH2:41][CH2:42][CH3:43])=[CH:35][CH:34]=2)=[O:32])[CH:22]=1)=[O:19])=[O:14])([CH3:9])([CH3:8])[CH3:7]>ClCCl>[CH2:40]([O:39][C:36]1[CH:35]=[CH:34][C:33]([C:31](=[O:32])[CH:30]([Cl:4])[C:29]([NH:28][C:23]2[CH:22]=[C:21]([O:20][C:18]([CH2:17][CH2:16][O:15][C:13](=[O:14])[C:12]3[CH:11]=[C:10]([C:6]([CH3:7])([CH3:8])[CH3:9])[C:47]([OH:48])=[C:46]([C:49]([CH3:51])([CH3:50])[CH3:52])[CH:45]=3)=[O:19])[CH:26]=[CH:25][C:24]=2[Cl:27])=[O:44])=[CH:38][CH:37]=1)[CH2:41][CH2:42][CH3:43]