Sulfuryl chloride → 2-{3-[3-(4-n-Butoxyphenyl)-2-chloro-3-oxopropanamido]-4-chlorophenylcarboxy}ethyl-3,5-di-t-butyl-4-hydroxybenzoate

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Reaction Steps

Sulphuryl chloride (4.9 g, 36.2 mmole) in dichloromethane (10 ml) was slowly added to a solution of the 4 equivalent coupler from (f) (24.1 g, 36.2 mmole) in dichloromethane (140 ml). After stirring at room temperature for 21 hours, the volatiles were removed by rotary evaporation. The product was isolated as a yellow oil (25.1 g, 99%) and was used in the next reaction without further purification.

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