Hydrochloric Acid → SC 44942-A

HRID 845384Notes

Reaction equation

HRID 845384 reaction equation
[CH3:1][C:2]1([CH3:27])[CH2:26][N:6]2[C:7]3[C:12]([N+:13]([O-:21])=[C:14]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[C:5]2=[N:4][CH2:3]1)=[CH:11][C:10]([C:22]([F:25])([F:24])[F:23])=[CH:9][CH:8]=3.[ClH:28]>C(O)C>[ClH:28].[CH3:1][C:2]1([CH3:27])[CH2:26][N:6]2[C:7]3[C:12]([N+:13]([O-:21])=[C:14]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[C:5]2=[N:4][CH2:3]1)=[CH:11][C:10]([C:22]([F:24])([F:25])[F:23])=[CH:9][CH:8]=3

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 3082690HCID 3082690, compound

Product 1

HCID 3082689SC 44942-A

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2,3-Dihydro-2,2-dimethyl-5-phenyl-8-trifluoromethyl-1H-pyrimido[1,2-a]quinoxaline 6-oxide (70 g) was suspended in ethanol (500 ml) and cooled in an ice-bath. Gaseous hydrogen chloride was passed through the suspension until all solid had dissolved. The solvent was then removed in vacuo and the resulting solid recrystallized from hot ethyl acetate to yield 57.87 g of 2,3-dihydro-2,2-dimethyl-5-phenyl-8-trifluoromethyl-1H-pyrimido[ 1,2-a]quinoxaline 6-oxide hydrochloride as a bright yellow crystalline solid, m.p. 234° C., (Found: C, 58.43, H, 4.68, N, 10.15%; C20H19ClF3N3O requires C, 58.61, H, 4.67, N, 10.25%) and represented by the structural formula: ##STR15##

Workup

  1. temperaturecooled in an ice-bath
  2. dissolutionhad dissolved
  3. customThe solvent was then removed in vacuo
  4. customthe resulting solid recrystallized from hot ethyl acetate

Sources & evidence

ORD record
ord-7a7e72a543f34529aa19e7e326bed1e5
Source dataset
uspto-grants-1988_07
Patent number
US04758565

Reaction notes

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