Water → Comenic acid

HRID 845385Notes

Reaction equation

HRID 845385 reaction equation
C1C=CC(C[O:8][C:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([OH:18])=[O:17])[O:11][CH:10]=2)=CC=1.O>Cl>[CH:13]1[C:14](=[O:15])[C:9]([OH:8])=[CH:10][O:11][C:12]=1[C:16]([OH:18])=[O:17]

Participants

4

Reactant 2

HCID 962WaterHCID 64807825-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid

Product 1

HCID 68139Comenic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

34.5 q of 5-benzyloxy-4-pyrone-2-carboxylic acid was suspended in 500 ml of concentrated hydrochloric acid and 250 ml of water and reacted for 1 hour at 80° C. The reaction solution was cooled with ice, and the formed crystal was taken out by filtration, washed with water and then dried, to obtain 16.6 g of 5-hydroxy-4-pyrone-2-carboxylic acid.

Workup

  1. temperatureThe reaction solution was cooled with ice
  2. filtrationthe formed crystal was taken out by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-22c5b018814145899daed9269e9a0d09
Source dataset
uspto-grants-1988_07
Patent number
US04758557

Reaction notes

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