HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-methoxycarbonylacetyl-N-methoxycarbonylmethyl-beta-aminopropionic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl 3-[(2-methoxy-2-oxo-ethyl)amino]propanoate | HCID 43093191 | — |
| Reactant | Malonic acid methylester chloride | HCID 86615040 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-methoxycarbonylacetyl-N-methoxycarbonylmethyl-beta-aminopropionic acid methyl ester | HCID 86742266 | — |
Reaction Steps
Analogously to the procedure described in Example 1(a), from 35.0 g (0.2 mol) of N-(methoxycarbonylmethyl)-β-aminopropionic acid methyl ester, 33 ml (0.24 mol) of triethylamine and 36.2 g (0.24 mol) of malonic acid monomethyl ester chloride in 60 ml of methylene chloride there is obtained N-methoxycarbonylacetyl-N-methoxycarbonylmethyl-β-aminopropionic acid methyl ester in the form of a yellowish oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04758575 |
| Source dataset | uspto-grants-1988_07 |
| ORD ID | ord-2db7f8a059b84862940f624c53a20572 |
| Source note | uspto-grants-1988_07 |