Triethylamine → N-methoxycarbonylacetyl-N-methoxycarbonylmethyl-beta-aminopropionic acid methyl ester

HRID 845425Notes

Reaction equation

HRID 845425 reaction equation
[CH3:1][O:2][C:3](=[O:12])[CH2:4][CH2:5][NH:6][CH2:7][C:8]([O:10][CH3:11])=[O:9].C(N(CC)CC)C.[Cl-].[CH3:21][O:22][C:23](=[O:28])[CH2:24][C:25](O)=[O:26]>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:12])[CH2:4][CH2:5][N:6]([C:25](=[O:26])[CH2:24][C:23]([O:22][CH3:21])=[O:28])[CH2:7][C:8]([O:10][CH3:11])=[O:9]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 43093191Methyl 3-[(2-methoxy-2-oxo-ethyl)amino]propanoateHCID 86615040Malonic acid methylester chloride

Product 1

HCID 86742266N-methoxycarbonylacetyl-N-methoxycarbonylmethyl-beta-aminopropionic acid methyl ester

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Analogously to the procedure described in Example 1(a), from 35.0 g (0.2 mol) of N-(methoxycarbonylmethyl)-β-aminopropionic acid methyl ester, 33 ml (0.24 mol) of triethylamine and 36.2 g (0.24 mol) of malonic acid monomethyl ester chloride in 60 ml of methylene chloride there is obtained N-methoxycarbonylacetyl-N-methoxycarbonylmethyl-β-aminopropionic acid methyl ester in the form of a yellowish oil.

Sources & evidence

ORD record
ord-2db7f8a059b84862940f624c53a20572
Source dataset
uspto-grants-1988_07
Patent number
US04758575

Reaction notes

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