Ammonium Hydroxide → HCID 14183122, compound

HRID 845444Notes

Reaction equation

HRID 845444 reaction equation
[SH:1][C:2]1[S:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[O:13][CH3:14])[N:3]=1.[O-]Cl.[Na+].[OH-].[NH4+:19]>[OH-].[Na+].O>[CH3:14][O:13][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[C:4]1[N:3]=[C:2]([S:1][NH2:19])[S:6][N:5]=1

Participants

6

Reactant 3

HCID 14923Ammonium HydroxideHCID 23665760Sodium HypochloriteHCID 178489423HCID 178489423, compound

Product 1

HCID 14183122HCID 14183122, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Procedure

A solution of 4.6 g of 5-mercapto-3-(2-methoxyphenyl)-1,2,4-thiadiazole in 70 ml of 5% sodium hydroxide and a solution prepared by diluting 44 ml of 5.25% NaOCl to 70 ml with water were added dropwise simultaneously to 190 ml of ammonium hydroxide solution while maintaining the mixture at 0° with an ice/methanol bath. The resulting mixture was stirred for 10 minutes and the solids were collected, washed with water and dried under high vacuum (with P2O5) to give 3.0 g of solid, m.p. 136°-138° C. dec.

Workup

  1. temperaturewhile maintaining the mixture at 0° with an ice/methanol bath
  2. customthe solids were collected
  3. washwashed with water
  4. dry with materialdried under high vacuum (with P2O5)

Sources & evidence

ORD record
ord-c415983821fb463a9bde3908ff78e896
Source dataset
uspto-grants-1988_07
Patent number
US04758578

Reaction notes

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