Ammonium Hydroxide → HCID 14183127, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 29.5 g of 5-mercapto-3-(2-fluorophenyl)-1,2,4-thiadiazole in 550 ml of 4.5% NaOH and a solution prepared by diluting 180 ml of 10% NaOCl to 550 ml with water were added dropwise simultaneously to 1450 ml of NH4OH solution maintained at 0° C. with an ice/methanol bath. The resulting mixture was stirred for 30 minutes and the solids were collected, washed with water and dried under high vacuum (P2O5) to give 19.0 g of solid, mp 151°-2° dec.

Provenance & Evidence