Ammonium Hydroxide → HCID 14183127, compound

HRID 845464Notes

Reaction equation

HRID 845464 reaction equation
[SH:1][C:2]1[S:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[F:13])[N:3]=1.[O-]Cl.[Na+].[NH4+:17].[OH-]>[OH-].[Na+].O>[F:13][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[C:4]1[N:3]=[C:2]([S:1][NH2:17])[S:6][N:5]=1

Participants

6

Reactant 3

HCID 14923Ammonium HydroxideHCID 23665760Sodium HypochloriteHCID 178505615HCID 178505615, compound

Product 1

HCID 14183127HCID 14183127, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Conditions

Temperature
0 °C

Procedure

A solution of 29.5 g of 5-mercapto-3-(2-fluorophenyl)-1,2,4-thiadiazole in 550 ml of 4.5% NaOH and a solution prepared by diluting 180 ml of 10% NaOCl to 550 ml with water were added dropwise simultaneously to 1450 ml of NH4OH solution maintained at 0° C. with an ice/methanol bath. The resulting mixture was stirred for 30 minutes and the solids were collected, washed with water and dried under high vacuum (P2O5) to give 19.0 g of solid, mp 151°-2° dec.

Workup

  1. customthe solids were collected
  2. washwashed with water
  3. dry with materialdried under high vacuum (P2O5)

Sources & evidence

ORD record
ord-1e361f29bcb1423ab0e3aaec1f8d1542
Source dataset
uspto-grants-1988_07
Patent number
US04758578

Reaction notes

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