Ammonia → HCID 86742271, compound

HRID 845497Notes

Reaction equation

HRID 845497 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[C@@H:14]2[C@@H:9]([CH2:10][CH2:11][CH2:12][CH2:13]2)[CH2:8][C:7]1=[O:15])C.N.O=C1[N:23](CC(N)=O)[C@H]2CCC[C@H]2C1>CO>[O:15]=[C:7]1[N:6]([CH2:5][C:4]([NH2:23])=[O:3])[C@H:14]2[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]2[CH2:8]1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 86742267HCID 86742267, compoundHCID 86742272HCID 86742272, compound

Product 1

HCID 86742271HCID 86742271, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of cis-octahydro-2-oxo-1H-indole-1acetic acid ethyl ester (15.43 g, 0.068 mole) in methanol (200 ml) is saturated with ammonia and stirred at ambient temperatures 24 hours. The solution is concentrated at reduced pressure to yield a solid. cis-Hexahydro-2-oxo-cyclopenta[b]pyrrole-1(2H)-acetamide with a mp 145°-145.5° C.

Workup

  1. concentrationThe solution is concentrated at reduced pressure
  2. customto yield a solid

Sources & evidence

ORD record
ord-575be8da29294df2b3db027c8f16a8d2
Source dataset
uspto-grants-1988_07
Patent number
US04758585

Reaction notes

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