Ammonia → HCID 14182978, compound

HRID 845498Notes

Reaction equation

HRID 845498 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[C@H:14]2[C@@H:9]([CH2:10][CH2:11][CH2:12][CH2:13]2)[CH2:8][C:7]1=[O:15])C.[NH3:17]>CO>[O:15]=[C:7]1[N:6]([CH2:5][C:4]([NH2:17])=[O:3])[C@@H:14]2[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]2[CH2:8]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 70406985HCID 70406985, compound

Product 1

HCID 14182978HCID 14182978, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A solution of trans-octahydro-2-oxo-1H-indole-1-acetic acid ethyl ester; (7.7 g, 0.032 mole) in methanol (200 ml) in methanol (200 ml) is saturated with ammonia and stirred at ambient temperatures 24 hours. The solution is concentrated at reduced pressure to yield a solid, trans-hexahydro-2-oxocyclohexa[b]pyrrol-1-(2H)-acetamide.

Workup

  1. concentrationThe solution is concentrated at reduced pressure

Sources & evidence

ORD record
ord-71853acb481a48cf80a1471e3910314b
Source dataset
uspto-grants-1988_07
Patent number
US04758585

Reaction notes

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