Ammonia → HCID 86742274, compound

HRID 845500Notes

Reaction equation

HRID 845500 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[C:10](=[O:11])[CH2:9][C@@H:8]2[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C@H:7]12)C.[NH3:19].C(OCC)C>CO>[O:11]=[C:10]1[N:6]([CH2:5][C:4]([NH2:19])=[O:3])[C@H:7]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][C@H:8]2[CH2:9]1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 3283Diethyl EtherHCID 86742270HCID 86742270, compound

Product 1

HCID 86742274HCID 86742274, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of cis-decahydro-2-oxo-1H-cycloocta[b]pyrrole-1-acetic acid ethyl ester (4.0 g, 0.0157 mole) in methanol (30 ml) is saturated with anhydrous ammonia. The solution is stirred 18 hours. The solution is concentrated at reduced pressure to yield a solid. Trituration with anhydrous diethyl ether yields pure cis-decahydro-2-oxo-1H-cycloocta[b]pyrrole-1-acetamide with mp 110°-112° C.

Workup

  1. concentrationThe solution is concentrated at reduced pressure
  2. customto yield a solid

Sources & evidence

ORD record
ord-9c153175249c4b66814348464bcb464f
Source dataset
uspto-grants-1988_07
Patent number
US04758585

Reaction notes

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