HCID 54180226, compound → HCID 53769050, compound

HRID 845508Notes

Reaction equation

HRID 845508 reaction equation
C([C:3]([CH:10]=[CH:11][C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:13]=1)=[C:4]([CH2:8][CH3:9])[C:5]([OH:7])=[O:6])C>CCOCC>[CH2:21]([N:14]1[C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:12]([CH:11]=[CH:10][CH:3]=[C:4]([CH2:8][CH3:9])[C:5]([OH:7])=[O:6])=[CH:13]1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

3

Reactant 1

HCID 54180226HCID 54180226, compound

Product 1

HCID 53769050HCID 53769050, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

In a manner similar to Example 2, 1.8 g (5 mmol) of ethyl 5-(1-benzylindol-3-yl)-2-ethyl-2,4-pentadienoic acid was hydrolyzed to give the corresponding acid, m.p. (ether): 169-170. NMR (CDCl3 /DMSO-d6) spectrum shows broad triplet and quartet at δ1.10 and δ2.47 respectively; the benzyl methylene signal appears at δ5.30 as a broad singlet.

Sources & evidence

ORD record
ord-bf067b3334024174a0ec67ef6a100734
Source dataset
uspto-grants-1988_07
Patent number
US04758586

Reaction notes

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