Methane → HCID 23035913, compound

HRID 845681Notes

Reaction equation

HRID 845681 reaction equation
[F:1][C:2]([F:18])([F:17])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11]([N:14]=[C:15]=[O:16])(=[O:13])=[O:12].[NH2:19][C:20]1[N:25]=[C:24]([O:26][CH3:27])[N:23]=[C:22]([O:28][CH3:29])[N:21]=1.C>O1CCOCC1>[F:18][C:2]([F:1])([F:17])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11]([NH:14][C:15]([NH:19][C:20]1[N:25]=[C:24]([O:26][CH3:27])[N:23]=[C:22]([O:28][CH3:29])[N:21]=1)=[O:16])(=[O:13])=[O:12]

Participants

5

Reactant 3

HCID 297MethaneHCID 278402-Amino-4,6-dimethoxy-1,3,5-triazineHCID 10684051HCID 10684051, compound

Product 1

HCID 23035913HCID 23035913, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5.6 g of 2-(3,3,3-trifluoropropyl)-phenylsulfonylisocyanate and 3.12 g of 2-amino-4,6-dimethoxy-1,3,5-triazine are stirred up in 60 ml of absolute dioxane at 70°-80° C. for 2 hours. The mixture is subsequently treated with active charcoal, filtered, and concentrated by evaporation to about 1/5 of the volume. There crystallise from the residue, after the addition of ether, 6.8 g of N-[2-(3,3,3-trifluoropropyl)-phenylsulfonyl]-N'-(4,6-dimethoxy-1,3,5-triazin-2-yl)-urea, m.p. 177°-178° C.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated by evaporation to about 1/5 of the volume
  3. customThere crystallise from the residue
  4. additionafter the addition of ether, 6.8 g of N-[2-(3,3,3-trifluoropropyl)-phenylsulfonyl]-N'-(4,6-dimethoxy-1,3,5-triazin-2-yl)-urea, m.p. 177°-178° C.

Sources & evidence

ORD record
ord-e6953a5a28c4407aa68304784147ff2a
Source dataset
uspto-grants-1988_07
Patent number
US04759793

Reaction notes

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