反应详情

Norfloxacin (6.4 g) was suspended in 300 ml of chloroform and 4.3 g of proton sponge® was added to it. The suspension was cooled in an ice bath and 4.0 g of 1-chloroethyl chloroformate was added. A clear solution resulted in half an hour. The reaction mixture was stirred at room temperature for 14 hours. The reaction mixture was concentrated in vacuum to about 150 ml. The crystals formed were filtered and washed with chloroform. The pure product weighed 5.3 g.

1. temperatureThe suspension was cooled in an ice bath
2. customA clear solution resulted in half an hour
3. concentrationThe reaction mixture was concentrated in vacuum to about 150 ml
4. customThe crystals formed
5. filtrationwere filtered
6. washwashed with chloroform