HCID 14072011, compound → HCID 13604886, compound

HRID 845742Notes

Reaction equation

HRID 845742 reaction equation
O[C:2]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[N:11][CH:12]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH:14]=2)[CH2:4][CH2:3]1>Cl>[C:22]1([C:2]2[CH2:7][CH2:6][N:5]([CH2:8][C:9]3[CH:10]=[N:11][CH:12]=[C:13]([C:15]4[CH:16]=[CH:17][C:18]([F:21])=[CH:19][CH:20]=4)[CH:14]=3)[CH2:4][CH:3]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 1

HCID 14072011HCID 14072011, compound

Product 1

HCID 13604886HCID 13604886, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

3.62 g of 3-(4-hydroxy-4-phenyl-1-piperidyl-methyl)-5-p-fluorophenyl-pyridine (obtainable by reaction of 3-bromomethyl-5-p-fluorophenyl-pyridine with 4-piperidone, subsequent reaction with C6H5Li and hydrolysis) are heated at 50° with 40 ml of 1 N hydrochloric acid for 2 hours and the mixture is worked up in the customary manner to give 3-(4-phenyl-1,2,3, 6-tetrahydropyridyl-methyl)-5-p-fluorophenyl-pyridine, melting point: 128°-129°.

Sources & evidence

ORD record
ord-04240227916543c391c10607ef488e8b
Source dataset
uspto-grants-1988_07
Patent number
US04760082

Reaction notes

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