Ethanol → 1-(4-Aminobenzoyl)-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril

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Reaction Steps

To a mixture of 1-(4-nitrobenzoyl)-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril (1.5 g) and ethanol (30 ml) were added DMF (5 ml) and 10% palladium on carbon (300 mg). The mixture was hydrogenated at 50° to 60° C. After competion of reaction, the catalyst was filtered off and the filtrate was evaporated under reduced pressure. The resultant residue was purified by silica-gel column chromatography (eluent:dichloromethane:methanol= 100:2) and recrystallized from ethanol to give 1-(4-aminobenzoyl)-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril (0.45 g).

Provenance & Evidence