Hydrogen Bromide → HCID 13588085, compound

HRID 845785Notes

Reaction equation

HRID 845785 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11]2[N:15]([CH2:16][C:17]3[CH:22]=[CH:21][C:20]([O:23]C)=[CH:19][CH:18]=3)[C:14]3[CH:25]=[CH:26][CH:27]=[CH:28][C:13]=3[N:12]=2)[CH2:6][CH2:5]1.[BrH:29]>O>[OH2:23].[BrH:29].[BrH:29].[BrH:29].[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11]2[N:15]([CH2:16][C:17]3[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=3)[C:14]3[CH:25]=[CH:26][CH:27]=[CH:28][C:13]=3[N:12]=2)[CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 13588054HCID 13588054, compound

Product 1

HCID 13588085HCID 13588085, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 7.5 parts of N-[1-(2-aminoethyl)-4-piperidinyl]-1-[(4-methoxyphenyl)methyl]-1H-benzimidazol-2-amine and 225 parts of a hydrobromic acid solution 48% in water was stirred and heated over week-end. After cooling, the precipitated product was filtered off and dried, yielding 7.3 parts (57%) of 4-[[2-[[1-(2-aminoethyl)-4-piperidinyl]amino]-1H-benzimidazol-1-yl]methyl]phenol trihydrobromide monohydrate; mp. >250° C. (intermediate 139).

Workup

  1. temperatureheated over week-end
  2. temperatureAfter cooling
  3. filtrationthe precipitated product was filtered off
  4. customdried

Sources & evidence

ORD record
ord-1bf71c2d17cc40618eef0d067f6ea0d1
Source dataset
uspto-grants-1988_07
Patent number
US04760074

Reaction notes

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