Hydrogen Bromide → HCID 13588088, compound

HRID 845786Notes

Reaction equation

HRID 845786 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11]2[N:15]([CH2:16][C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)[C:14]3[CH:24]=[CH:25][C:26]([O:28]C)=[CH:27][C:13]=3[N:12]=2)[CH2:6][CH2:5]1.[BrH:30]>O>[OH2:28].[BrH:30].[BrH:30].[BrH:30].[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11]2[N:15]([CH2:16][C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)[C:14]3[CH:24]=[CH:25][C:26]([OH:28])=[CH:27][C:13]=3[N:12]=2)[CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 13588086HCID 13588086, compound

Product 1

HCID 13588088HCID 13588088, compoundYield 95.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 12 parts of N-[1-(2-aminoethyl)-4-piperidinyl]-1-[(4-fluorophenyl)methyl]-5-methoxy-1H-benzimidazol-2-amine and 150 parts of a hydrobromic acid solution 48% in water was stirred and heated for 48 hours at 80° C. The reaction mixture was evaporated and the residue was suspended in 2-propanol. The product was filtered off and dried, yielding 18.5 parts (95.7%) of 2-[[1-(2-aminoethyl)-4-piperidinyl]amino]-1-[(4-fluorophenyl)methyl]-1H-benzimidazol-5-ol trihydrobromide monohydrate; mp. +250° C. (intermediate 140).

Workup

  1. customThe reaction mixture was evaporated
  2. filtrationThe product was filtered off
  3. customdried

Sources & evidence

ORD record
ord-4810ca0928bc46b1a0726107bdb9868d
Source dataset
uspto-grants-1988_07
Patent number
US04760074

Reaction notes

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