反应详情

温度

15 °C

45.5 g of formyl-α-L-aspartyl-L-phenylalanine is dissolved in concentrated hydrogen chloride (18.2 ml) and water (141 ml). The mixture is treated at 60° C. for 4 hours to remove the formyl group. 11.7 g of 50% caustic solution is added into the resulting solution and cooled to 15° C. to obtain a precipitate of α-L-aspartyl-L-phenylalanine. After filtration, the precipitate is washed with 10 ml of water at 5° C. and dried to obtain 25.2 g (0.090 mole) of the desired product. The remaining filtrate is mixed with 50% caustic solution (6.5 g) and cooled to obtain the precipitate by filtration. The precipitate is washed with water (10 ml) at 5° C. and dried to obtain additional α-L-aspartyl-L-phenylalanine (12.2 g, 0.043 mole).

1. additionThe mixture is treated at 60° C. for 4 hours
2. customto remove the formyl group
3. addition11.7 g of 50% caustic solution is added into the resulting solution