Hydrochloric Acid → HCID 131715648, compound

HRID 845894Notes

Reaction equation

HRID 845894 reaction equation
C([O:8][C:9]1[CH:42]=[C:41]([CH3:43])[C:12]([CH2:13][CH:14]([C:24]([NH:26][C@@H:27]([C:29]([N-:31][CH2:32][CH2:33][CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)=[O:30])[CH3:28])=[O:25])[N:15]([C:17](OC(C)(C)C)=O)C)=[C:11]([CH3:44])[CH:10]=1)C1C=CC=CC=1.CO.[ClH:47]>O1CCOCC1>[ClH:47].[CH3:17][NH:15][CH:14]([C:24]([NH:26][C@@H:27]([C:29]([NH:31][CH2:32][CH2:33][CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:30])[CH3:28])=[O:25])[CH2:13][CH:12]1[C:11]([CH3:44])=[CH:10][C:9]([OH:8])=[CH:42][C:41]1([CH3:43])[CH2:44][C:11]1[CH:12]=[CH:41][CH:42]=[CH:9][CH:10]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 178428943HCID 178428943, compound

Product 1

HCID 131715648HCID 131715648, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

O-Benzyl-N-methyl-BOC-2,6-dimethyl (DL)-tyrosyl-(D)-alanylphenylpropylamide was treated with methanol (1.5 ml) and 6.8N HCl in dioxane (1 ml) for 24 hr. The mixture was evaporated in a stream of nitrogen, and dissolved in aqueous methanol. The solution was filtered through Whatman 50 filter paper, reduced in volume in a nitrogen stream, and lyophilized. The product is

Workup

  1. customThe mixture was evaporated in a stream of nitrogen
  2. dissolutiondissolved in aqueous methanol
  3. filtrationThe solution was filtered through Whatman 50
  4. filtrationfilter paper

Sources & evidence

ORD record
ord-17c8194914b74d208da2f92a9286c433
Source dataset
uspto-grants-1988_07
Patent number
US04760180

Reaction notes

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