Sodium → HCID 20130679, compound

HRID 845905Notes

Reaction equation

HRID 845905 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH:18][CH:19]=[C:20]([C:22]([O:24]C)=O)[CH3:21])=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[Na]>C(O)(C)C.CN(C)C=O>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:22](=[O:24])[C:20]([CH3:21])=[CH:19][NH:18][C:16]2=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 54564066Isopropyl 2-chloro-4-fluoro-5-{3-[2-(methoxycarbonyl)propenyl]ureido}-benzoate

Product 1

HCID 20130679HCID 20130679, compound

Reagents, catalysts & solvents 1

HCID 20197112Isopropanol dimethylformamideSolvent

Procedure

using isopropyl 2-chloro-4-fluoro-5-{3-[2-(methoxycarbonyl)propenyl]ureido}-benzoate with sodium isopropylate in an isopropanol/dimethylformamide mixture there is obtained isopropyl 2-chloro-4-fluoro-5-[3,6-dihydro-5-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate, m.p. 170°-173° C.,

Sources & evidence

ORD record
ord-26c4283741b44732b0be297e3842a7cc
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

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