Sodium ethoxide → ethyl 2-chloro-5-{1,2,5,7-tetrahydro-2,4-dioxo-thieno[3,4-d]pyrimidin-3(4H)-yl}-benzoate

HRID 845909Notes

Reaction equation

HRID 845909 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([NH:16][C:17]2[CH2:18][S:19][CH2:20][C:21]=2[C:22]([O:24]C)=O)=[O:15])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].CC[O-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:12]=[CH:11][C:10]([N:13]2[C:22](=[O:24])[C:21]3[CH2:20][S:19][CH2:18][C:17]=3[NH:16][C:14]2=[O:15])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 2723922Sodium ethoxideHCID 20130667Ethyl 2-chloro-5-{3-[4-(methoxycarbonyl)-2,5-dihydro-thien-3-yl]ureido}-benzoate

Product 1

HCID 20130698ethyl 2-chloro-5-{1,2,5,7-tetrahydro-2,4-dioxo-thieno[3,4-d]pyrimidin-3(4H)-yl}-benzoate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

using ethyl 2-chloro-5-{3-[4-(methoxycarbonyl)-2,5-dihydro-thien-3-yl]ureido}-benzoate with sodium ethylate in ethanol there is obtained ethyl 2-chloro-5-{1,2,5,7-tetrahydro-2,4-dioxo-thieno[3,4-d]pyrimidin-3(4H)-yl}-benzoate, m.p. 194°-196° C.,

Sources & evidence

ORD record
ord-a29cfe18aa464f9696f0de53bd47e029
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

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