Dimethyl Sulfate → HCID 20130584, compound

HRID 845934Notes

Reaction equation

HRID 845934 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([F:22])=[C:18]([CH3:23])[NH:17][C:16]2=[O:24])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].S(OC)(O[CH3:29])(=O)=O>CN(C)C=O>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([F:22])=[C:18]([CH3:23])[N:17]([CH3:29])[C:16]2=[O:24])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 6497Dimethyl SulfateHCID 20130582HCID 20130582, compound

Product 1

HCID 20130584HCID 20130584, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

using isopropyl 2-chloro-4-fluoro-5-[3,6-dihydro-5-fluoro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate and dimethyl sulphate in dimethylformamide there is obtained isopropyl 2-chloro-4-fluoro-5-[3,6-dihydro-3,4-dimethyl-5-fluoro-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate, m.p. 112°-115° C.,

Sources & evidence

ORD record
ord-e1fd2808851d487183d9bea3fd920593
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

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