Dimethyl Sulfate → HCID 20130668, compound

HRID 845948Notes

Reaction equation

HRID 845948 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([F:22])=[C:18]([CH2:23][F:24])[NH:17][C:16]2=[O:25])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].S(OC)(O[CH3:30])(=O)=O>CN(C)C=O>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([F:22])=[C:18]([CH2:23][F:24])[N:17]([CH3:30])[C:16]2=[O:25])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 6497Dimethyl SulfateHCID 20130618HCID 20130618, compound

Product 1

HCID 20130668HCID 20130668, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

using isopropyl 2-chloro-4-fluoro-5-[3,6-dihydro-5-fluoro-4-fluoromethyl-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate and dimethyl sulphate in dimethylformamide there is obtained isopropyl 2-chloro-4-fluoro-5-[3,6-dihydro-5-fluoro-4-fluoromethyl-3methyl-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate, m.p. 85°-89° C.,

Sources & evidence

ORD record
ord-abbfce66e80f42b49055e31bbf7a9219
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

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