HCID 20130647, compound → HCID 20130675, compound

HRID 845957Notes

Reaction equation

HRID 845957 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([CH2:22]Cl)=[C:18]([CH3:24])[N:17]([CH3:25])[C:16]2=[O:26])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]>C(O)(C)C>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([CH2:22][O:6][CH:7]([CH3:9])[CH3:8])=[C:18]([CH3:24])[N:17]([CH3:25])[C:16]2=[O:26])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

3

Reactant 1

HCID 20130647HCID 20130647, compound

Product 1

HCID 20130675HCID 20130675, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

using isopropyl 2-chloro-4-fluoro-5-[5-chloromethyl-3,6-dihydro-3,4-dimethyl-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate with isopropanol there is obtained isopropyl 2-chloro-4-fluoro-5-[3,6-dihydro-3,4-dimethyl-5-isopropoxymethyl-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate, 1H--NMR (CDCl3, 400 MHz) 7.82 ppm (d, 1H), 7.32 ppm (d, 1H), 5.22 ppm (m, 1H), 4.45 ppm (d, 1H), 4.34 ppm (d, 1H), 3.69 ppm (m, 1H), 3.48 ppm (s, 3H), 2.44 ppm (s, 3H), 1.35 ppm (d, 6H), 1.21 ppm (d, 6H).

Sources & evidence

ORD record
ord-9a3fea9eeb4a404882549da3bf89b58f
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

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