3-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester → Ethyl 2-chloro-5-{3-[4-(methoxycarbonyl)-2,5-dihydro-thien-3-yl]ureido}-benzoate

HRID 845978Notes

Reaction equation

HRID 845978 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([NH2:16])=[O:15])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].O=[C:18]1[CH:22]([C:23]([O:25][CH3:26])=[O:24])[CH2:21][S:20][CH2:19]1>>[Cl:1][C:2]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([NH:16][C:18]2[CH2:19][S:20][CH2:21][C:22]=2[C:23]([O:25][CH3:26])=[O:24])=[O:15])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

3

Reactant 2

HCID 984243-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl esterHCID 21270735Ethyl 2-chloro-5-ureidobenzoate

Product 1

HCID 20130667Ethyl 2-chloro-5-{3-[4-(methoxycarbonyl)-2,5-dihydro-thien-3-yl]ureido}-benzoate

Procedure

using ethyl 2-chloro-5-ureidobenzoate and methyl 3-oxotetrahydrothiophene-4-carboxylate there is obtained ethyl 2-chloro-5-{3-[4-(methoxycarbonyl)-2,5-dihydro-thien-3-yl]ureido}-benzoate

Sources & evidence

ORD record
ord-ecbd5d5cf0234dfe85029adfdcf1e4f3
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

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