3-Cyanopyridine → Nicotinic Acid

HRID 846039Notes

Reaction equation

HRID 846039 reaction equation
[C:1](#N)[CH:2]=[CH2:3].[C:5]([C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)#N.P([O-])([O-])([O-])=[O:14].[K+].[K+].[K+].[OH2:21]>>[C:1]([OH:14])(=[O:21])[CH:2]=[CH2:3].[C:5]([OH:14])(=[O:21])[C:7]1[CH:12]=[CH:11][CH:10]=[N:9][CH:8]=1

Participants

6

Reactant 4

HCID 793-CyanopyridineHCID 962WaterHCID 7855AcrylonitrileHCID 62657Potassium Phosphate, Tribasic

Product 2

HCID 938Nicotinic AcidHCID 6581Acrylic Acid

Procedure

Each of the cell suspensions was added in an amount of 0.1 ml to a reaction solution comprising 50 mM acrylonitrile or 1.0 ml of 3-cyanopyridine, 0.5 ml of a 100 mM potassium phosphate buffer pH 7.8 and 0.4 ml of distilled water, and the reaction was conducted at 20° C. for 20 minutes. The reaction was terminated by the addition of 0.2 ml of 1N HCl, and the amount of acrylic acid or nicotinic acid produced was assayed by HPLC wherein the M&S Pack Cl8 column manufactured by MS Kiki, Inc., Japan was used.

Workup

  1. additionEach of the cell suspensions was added in an amount of 0.1 ml to a reaction solution
  2. customThe reaction was terminated by the addition of 0.2 ml of 1N HCl

Sources & evidence

ORD record
ord-69bd3283ff7f456994bbb0e3098ff730
Source dataset
uspto-grants-1992_08
Patent number
US05135858

Reaction notes

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