HCID 19014057, compound → HCID 19014054, compound

HRID 846046Notes

Reaction equation

HRID 846046 reaction equation
C([CH:5]([C:17]([OH:19])=[O:18])[O:6][C:7]1[CH:8]=[C:9]([CH2:13][C:14](=[O:16])[CH3:15])[CH:10]=[CH:11][CH:12]=1)(C)(C)C>FC(F)(F)C(O)=O>[C:17]([CH2:5][O:6][C:7]1[CH:8]=[C:9]([CH2:13][C:14](=[O:16])[CH3:15])[CH:10]=[CH:11][CH:12]=1)([OH:19])=[O:18]

Participants

3

Reactant 1

HCID 19014057HCID 19014057, compound

Product 1

HCID 19014054HCID 19014054, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

To m-(t-butylcarboxymethoxy)phenyl acetone, 6.7 g, was added trifluoroacetic acid (40 ml) at room temperature under nitrogen. After five minutes, reaction was found to be completed by tlc (silica gel eluted with 1:9 parts by volume methanol:methylene chloride) and the solvent was then evaporated to dryness. The resulting brown oil showed the desired product and trace of starting material on tlc. IR showed characteristic carboxylic acid peak at 3600-2450 cm-1.

Workup

  1. customreaction
  2. washto be completed by tlc (silica gel eluted with 1:9 parts by volume methanol:methylene chloride)
  3. customthe solvent was then evaporated to dryness

Sources & evidence

ORD record
ord-42c009f3d0b44032b09f074e36fbecbc
Source dataset
uspto-grants-1992_08
Patent number
US05135863

Reaction notes

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