Hydrazine hydrate (1:1) → HCID 14884394, compound

HRID 846093Notes

Reaction equation

HRID 846093 reaction equation
O=[C:2]([C:9]1[CH:14]=[CH:13][C:12]([S:15]([CH2:18][CH2:19][CH2:20][N:21]2[C:25](=[O:26])[C:24]3=[CH:27][CH:28]=[CH:29][CH:30]=[C:23]3[C:22]2=[O:31])(=[O:17])=[O:16])=[CH:11][CH:10]=1)[CH2:3][CH2:4][C:5]([O:7]C)=O.O.[NH2:33][NH2:34]>C(O)(=O)C>[C:25]1(=[O:26])[N:21]([CH2:20][CH2:19][CH2:18][S:15]([C:12]2[CH:13]=[CH:14][C:9]([C:2]3[CH2:3][CH2:4][C:5](=[O:7])[NH:33][N:34]=3)=[CH:10][CH:11]=2)(=[O:16])=[O:17])[C:22](=[O:31])[C:23]2=[CH:30][CH:29]=[CH:28][CH:27]=[C:24]12

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 14884393HCID 14884393, compound

Product 1

HCID 14884394HCID 14884394, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

34 g (78.2 mmol) of methyl 4-oxo-4-[4-(3-phthalimidopropylsulphonyl)phenyl]butyrate are refluxed for two hours in a solution of 6 ml (120 mmol) of hydrazine hydrate (99%) in 350 ml of glacial acetic acid. Then the mixture is poured onto 2.5 liters of ice water, the product precipitated is suction filtered and dried in a circulating air dryer at 80° C.

Workup

  1. customthe product precipitated
  2. filtrationfiltered
  3. customdried in a circulating air dryer at 80° C.

Sources & evidence

ORD record
ord-b9600310c06d49fb88ebe97e689bda2f
Source dataset
uspto-grants-1992_08
Patent number
US05135932

Reaction notes

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