Hydrochloric Acid → HCID 14884401, compound

Participants

Reaction Steps

A mixture of 6.8 g (18 mmol) of 6-[4-((2-tert.butoxycarbonylaminoethyl)aminocarbonylmethyl)phenyl]4,5-dihydro-3(2H)-pyridazinone, 25 ml of ethanol and 50 ml of 2N hydrochloric acid is refluxed for about 2 minutes, then the ethanol is distilled off, the aqueous solution is made alkaline with concentrated ammonia solution and finally the precipitate is suction filtered. This product is purified by chromatography on 200 g of silica gel (eluant: dichloromethane/methanol/ammonia=70:30:1).

Provenance & Evidence