Hydrochloric Acid → HCID 14884401, compound

HRID 846098Notes

Reaction equation

HRID 846098 reaction equation
C(OC([NH:8][CH2:9][CH2:10][NH:11][C:12]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH2:22][CH2:23][C:24](=[O:27])[NH:25][N:26]=2)=[CH:17][CH:16]=1)=[O:13])=O)(C)(C)C.Cl>C(O)C>[NH2:8][CH2:9][CH2:10][NH:11][C:12]([CH2:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]2[CH2:22][CH2:23][C:24](=[O:27])[NH:25][N:26]=2)=[CH:19][CH:20]=1)=[O:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14884400HCID 14884400, compound

Product 1

HCID 14884401HCID 14884401, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 6.8 g (18 mmol) of 6-[4-((2-tert.butoxycarbonylaminoethyl)aminocarbonylmethyl)phenyl]4,5-dihydro-3(2H)-pyridazinone, 25 ml of ethanol and 50 ml of 2N hydrochloric acid is refluxed for about 2 minutes, then the ethanol is distilled off, the aqueous solution is made alkaline with concentrated ammonia solution and finally the precipitate is suction filtered. This product is purified by chromatography on 200 g of silica gel (eluant: dichloromethane/methanol/ammonia=70:30:1).

Workup

  1. temperatureis refluxed for about 2 minutes
  2. distillationthe ethanol is distilled off
  3. filtrationfiltered
  4. customThis product is purified by chromatography on 200 g of silica gel (eluant: dichloromethane/methanol/ammonia=70:30:1)

Sources & evidence

ORD record
ord-95f3661f1b1d4e3197052c37b5d4f92d
Source dataset
uspto-grants-1992_08
Patent number
US05135932

Reaction notes

Loading…