Hydrochloric Acid → 6-[1-(2-Aminoethyl)benzimidazol-5-yl]-3(2H)-pyridazinone

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Reaction Steps

8.0 g (26.0 mmol) of 6-[1-(2-acetylaminoethyl)benzimidazol-5-yl]-3(2H)-pyridazinone are refluxed for 4 hours in 80 ml of 5N sodium hydroxide solution. After cooling the mixture is adjusted to pH 8-9 with concentrated hydrochloric acid, the product precipitated is suction filtered and dried in a vacuum drying cupboard. The crude product obtained is used again without any further purification.

Provenance & Evidence