Hydrochloric Acid → 6-[1-(2-Aminoethyl)benzimidazol-5-yl]-3(2H)-pyridazinone

HRID 846099Notes

Reaction equation

HRID 846099 reaction equation
C([NH:4][CH2:5][CH2:6][N:7]1[C:11]2[CH:12]=[CH:13][C:14]([C:16]3[CH:17]=[CH:18][C:19](=[O:22])[NH:20][N:21]=3)=[CH:15][C:10]=2[N:9]=[CH:8]1)(=O)C.Cl>[OH-].[Na+]>[NH2:4][CH2:5][CH2:6][N:7]1[C:11]2[CH:12]=[CH:13][C:14]([C:16]3[CH:17]=[CH:18][C:19](=[O:22])[NH:20][N:21]=3)=[CH:15][C:10]=2[N:9]=[CH:8]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 148843956-[1-(2-Acetylaminoethyl)benzimidazol-5-yl]-3(2H)-pyridazinone

Product 1

HCID 151078176-[1-(2-Aminoethyl)benzimidazol-5-yl]-3(2H)-pyridazinoneYield 99%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

8.0 g (26.0 mmol) of 6-[1-(2-acetylaminoethyl)benzimidazol-5-yl]-3(2H)-pyridazinone are refluxed for 4 hours in 80 ml of 5N sodium hydroxide solution. After cooling the mixture is adjusted to pH 8-9 with concentrated hydrochloric acid, the product precipitated is suction filtered and dried in a vacuum drying cupboard. The crude product obtained is used again without any further purification.

Workup

  1. temperatureAfter cooling the mixture
  2. customthe product precipitated
  3. filtrationfiltered
  4. customdried in a vacuum
  5. customdrying cupboard

Sources & evidence

ORD record
ord-8f60df03e8e0479f8635cb4ab8ee8032
Source dataset
uspto-grants-1992_08
Patent number
US05135932

Reaction notes

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