((o-Allylphenoxy)methyl)oxirane → 6-[2-[2-[3-(2-Allyl-phenoxy)-2-hydroxypropylamino]ethyl]benzimidazol-5-yl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone

HRID 846138Notes

Reaction equation

HRID 846138 reaction equation
[CH2:1]([C:4]1[CH:14]=[CH:13][CH:12]=[CH:11][C:5]=1[O:6][CH2:7][CH:8]1[O:10][CH2:9]1)[CH:2]=[CH2:3].[NH2:15][CH2:16][CH2:17][C:18]1[NH:19][C:20]2[CH:26]=[C:25]([C:27]3[CH:28]([CH3:34])[CH2:29][C:30](=[O:33])[NH:31][N:32]=3)[CH:24]=[CH:23][C:21]=2[N:22]=1>>[CH2:1]([C:4]1[CH:14]=[CH:13][CH:12]=[CH:11][C:5]=1[O:6][CH2:7][CH:8]([OH:10])[CH2:9][NH:15][CH2:16][CH2:17][C:18]1[NH:19][C:20]2[CH:26]=[C:25]([C:27]3[CH:28]([CH3:34])[CH2:29][C:30](=[O:33])[NH:31][N:32]=3)[CH:24]=[CH:23][C:21]=2[N:22]=1)[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 98437((o-Allylphenoxy)methyl)oxiraneHCID 144040656-[2-(2-aminoethyl)benzimidazol-5-yl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone

Product 1

HCID 151078476-[2-[2-[3-(2-Allyl-phenoxy)-2-hydroxypropylamino]ethyl]benzimidazol-5-yl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone

Procedure

Prepared analogously to Example 1 from 1-(2-allylphenoxy)-2,3-epoxypropane and 6-[2-(2-aminoethyl)benzimidazol-5-yl]-4,5-dihydro-5-methyl-3(2H)- pyridazinone.

Sources & evidence

ORD record
ord-418aa36be80e4e009409e0040c508989
Source dataset
uspto-grants-1992_08
Patent number
US05135932

Reaction notes

Loading…