1-(4-Methylsulphonyloxy-phenoxy)-2,3-epoxypropane → 6-[1-[2-[3-(4-Methylsulphonyloxy-phenoxy)-2-hydroxypropylamino]ethyl]benzimidazol-5-yl]-4,5-dihydro-3(2H)-pyridazinone

HRID 846142Notes

Reaction equation

HRID 846142 reaction equation
[CH3:1][S:2]([O:5][C:6]1[CH:16]=[CH:15][C:9]([O:10][CH2:11][CH:12]2[O:14][CH2:13]2)=[CH:8][CH:7]=1)(=[O:4])=[O:3].[NH2:17][CH2:18][CH2:19][N:20]1[C:24]2[CH:25]=[CH:26][C:27]([C:29]3[CH2:30][CH2:31][C:32](=[O:35])[NH:33][N:34]=3)=[CH:28][C:23]=2[N:22]=[CH:21]1>>[CH3:1][S:2]([O:5][C:6]1[CH:16]=[CH:15][C:9]([O:10][CH2:11][CH:12]([OH:14])[CH2:13][NH:17][CH2:18][CH2:19][N:20]2[C:24]3[CH:25]=[CH:26][C:27]([C:29]4[CH2:30][CH2:31][C:32](=[O:35])[NH:33][N:34]=4)=[CH:28][C:23]=3[N:22]=[CH:21]2)=[CH:8][CH:7]=1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 115505071-(4-Methylsulphonyloxy-phenoxy)-2,3-epoxypropaneHCID 151078536-[1-(2-aminoethyl)benzimidazol-5-yl]-4,5-dihydro-3(2H)-pyridazinone

Product 1

HCID 151078556-[1-[2-[3-(4-Methylsulphonyloxy-phenoxy)-2-hydroxypropylamino]ethyl]benzimidazol-5-yl]-4,5-dihydro-3(2H)-pyridazinone

Procedure

Prepared analogously to Example 1 from 1-(4-methylsulphonyloxy-phenoxy)-2,3-epoxypropane and 6-[1(2-aminoethyl)benzimidazol-5-yl]-4,5-dihydro-3(2H)-pyridazinone.

Sources & evidence

ORD record
ord-23451f168f5043468ba4c5f6cb105064
Source dataset
uspto-grants-1992_08
Patent number
US05135932

Reaction notes

Loading…