1-[4-(2-Isobutoxyethyl)phenoxy]-2,3-epoxypropane → 6-[1-[3-[3-(4-(2-Isobutoxyethyl)phenoxy)-2hydroxypropylamino]propyl]benzimidazol-5-yl]-4,5-dihydro-3-(2H)-pyridazinone

HRID 846144Notes

Reaction equation

HRID 846144 reaction equation
[CH2:1]([O:5][CH2:6][CH2:7][C:8]1[CH:18]=[CH:17][C:11]([O:12][CH2:13][CH:14]2[O:16][CH2:15]2)=[CH:10][CH:9]=1)[CH:2]([CH3:4])[CH3:3].[NH2:19][CH2:20][CH2:21][CH2:22][N:23]1[C:27]2[CH:28]=[CH:29][C:30]([C:32]3[CH2:33][CH2:34][C:35](=[O:38])[NH:36][N:37]=3)=[CH:31][C:26]=2[N:25]=[CH:24]1>>[CH2:1]([O:5][CH2:6][CH2:7][C:8]1[CH:18]=[CH:17][C:11]([O:12][CH2:13][CH:14]([OH:16])[CH2:15][NH:19][CH2:20][CH2:21][CH2:22][N:23]2[C:27]3[CH:28]=[CH:29][C:30]([C:32]4[CH2:33][CH2:34][C:35](=[O:38])[NH:36][N:37]=4)=[CH:31][C:26]=3[N:25]=[CH:24]2)=[CH:10][CH:9]=1)[CH:2]([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 151078061-[4-(2-Isobutoxyethyl)phenoxy]-2,3-epoxypropaneHCID 151078566-[1-(3-aminopropyl)benzimidazol-5-yl]-4,5-dihydro-3(2H)-pyridazinone

Product 1

HCID 148844476-[1-[3-[3-(4-(2-Isobutoxyethyl)phenoxy)-2hydroxypropylamino]propyl]benzimidazol-5-yl]-4,5-dihydro-3-(2H)-pyridazinone

Procedure

Prepared analogously to Example 1 from 1-[4-(2-isobutoxyethyl)-phenoxy]-2,3-epoxypropane and 6-[1-(3-aminopropyl)benzimidazol-5-yl]-4,5-dihydro-3(2H)-pyridazinone.

Sources & evidence

ORD record
ord-47ceee108c144f6ea1e987c31b69c34a
Source dataset
uspto-grants-1992_08
Patent number
US05135932

Reaction notes

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