p-Anisoyl chloride → HCID 14698596, compound

HRID 846207Notes

Reaction equation

HRID 846207 reaction equation
[C:1]([C:3]([C:6]1[CH:12]=[CH:11][C:9]([NH2:10])=[CH:8][CH:7]=1)([CH3:5])[CH3:4])#[N:2].[CH3:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=1>>[C:1]([C:3]([C:6]1[CH:7]=[CH:8][C:9]([NH:10][C:19](=[O:20])[C:18]2[CH:22]=[CH:23][C:15]([O:14][CH3:13])=[CH:16][CH:17]=2)=[CH:11][CH:12]=1)([CH3:5])[CH3:4])#[N:2]

Participants

3

Reactant 2

HCID 7477p-Anisoyl chlorideHCID 100578012-(4-Aminophenyl)-2-methylpropanenitrile

Product 1

HCID 14698596HCID 14698596, compoundYield 85%

Procedure

Analogously to Example 25, 4-(1-cyano-1-methylethyl)-aniline is reacted with 4-methoxybenzoic acid chloride to give a yield of 85% of theory of the title compound in the form of beige crystals; m.p. 169°-171° C. A sample thereof is recrystallised from ethanol and then has a melting point of 172°-174° C.

Sources & evidence

ORD record
ord-9d60ed0b4bee4089b1642f04d135403d
Source dataset
uspto-grants-1992_08
Patent number
US05135949

Reaction notes

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