Methyl iodide → HCID 19885224, compound

HRID 846259Notes

Reaction equation

HRID 846259 reaction equation
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][CH:14]([CH3:18])[N:15]([CH3:17])[CH3:16])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4].[I:19][CH3:20]>CCOCC>[I-:19].[CH2:1]([O:5][C:6]1[CH:7]=[CH:8][C:9]([CH2:12][CH2:13][CH:14]([CH3:18])[N+:15]([CH3:20])([CH3:17])[CH3:16])=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 19885131HCID 19885131, compound

Product 1

HCID 19885224HCID 19885224, compoundYield 31%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To an ether solution containing 1.0 g of 4-butoxy-N,N,α-trimethylbenzenepropanamine (the free base of the compound prepared in Example 41B) was added 2.5 ml of iodomethane and, over a period of 4 hours an oil separated from the solution. The solvent was evaporated and the residue was crystallized from ethyl acetate to give 0.48 g (31% yield) of the desired titled compound, m.p. 160°-165° C.

Workup

  1. customover a period of 4 hours an oil separated from the solution
  2. customThe solvent was evaporated
  3. customthe residue was crystallized from ethyl acetate

Sources & evidence

ORD record
ord-adf72e2b410b42d095614a443a70ea82
Source dataset
uspto-grants-1992_08
Patent number
US05135955

Reaction notes

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