HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2,4-Dimethylthiazole-5-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Dimethyl-1,3-thiazole-5-carboxylic acid | HCID 736488 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2,4-Dimethylthiazole-5-carbonyl chloride | HCID 14653140 | 41% |
Reaction Steps
15.7 g (0.1 mole) of 2,4-dimethylthiazole-5-carboxylic acid were suspended in 300 ml of ethyl ether and 8 g (0.1 mole) of pyridine, followed by the dropwise addition of 12 g (0.1 mole) of thionyl chloride at -3° C. for 45 minutes. After completion of the reaction, filtration and concentrating were conducted to obtain 7.2 g pf 2.4-dimethylthiazole-5-carboxylic acid chloride. Its purity and yield were 85% and 35%, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05136042 |
| Source dataset | uspto-grants-1992_08 |
| ORD ID | ord-be8d2fd0b17e44de9c37f27aa4272085 |
| Source note | uspto-grants-1992_08 |