Pyridine → 2,4-Dimethylthiazole-5-carbonyl chloride

HRID 846298Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 846298
[CH3:1][C:2]1[S:3][C:4]([C:8]([OH:10])=O)=[C:5]([CH3:7])[N:6]=1.N1C=CC=CC=1.S(Cl)([Cl:19])=O>C(OCC)C>[CH3:1][C:2]1[S:3][C:4]([C:8]([Cl:19])=[O:10])=[C:5]([CH3:7])[N:6]=1

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 736488Dimethyl-1,3-thiazole-5-carboxylic acid

Produkt 1

HCID 146531402,4-Dimethylthiazole-5-carbonyl chlorideAusbeute 41 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

15.7 g (0.1 mole) of 2,4-dimethylthiazole-5-carboxylic acid were suspended in 300 ml of ethyl ether and 8 g (0.1 mole) of pyridine, followed by the dropwise addition of 12 g (0.1 mole) of thionyl chloride at -3° C. for 45 minutes. After completion of the reaction, filtration and concentrating were conducted to obtain 7.2 g pf 2.4-dimethylthiazole-5-carboxylic acid chloride. Its purity and yield were 85% and 35%, respectively.

Aufarbeitung

  1. customAfter completion of the reaction, filtration
  2. concentrationconcentrating

Quellen und Nachweise

ORD-Eintrag
ord-be8d2fd0b17e44de9c37f27aa4272085
Quelldatensatz
uspto-grants-1992_08
Patentnummer
US05136042

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