Hydrochloric Acid → HCID 86746038, compound

HRID 846310Notes

Reaction equation

HRID 846310 reaction equation
[N:1]#[N:2].[C:3]([C@@H:5]([NH:14][C@H:15]([C:27]([OH:29])=[O:28])[CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21](=[O:26])[C:22]([F:25])([F:24])[F:23])[CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)#[N:4].Cl.[OH-:31].[Na+]>>[N:1]#[N:2].[C:3]([C@@H:5]([NH:14][C@H:15]([C:27]([OH:29])=[O:28])[CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21](=[O:26])[C:22]([F:23])([F:24])[F:25])[CH2:6][CH2:7][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)(=[O:31])[NH2:4]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86746040HCID 86746040, compound

Product 1

HCID 86746038HCID 86746038, compound

Procedure

After stirring a mixture of 12 g of N2 -(1(S)-cyano-3-phenylpropyl)-N6 -trifluoroacetyl-L-lysine and 40 ml of concentrated hydrochloric acid for 5 hours at room temperature, 200 ml of ice-water was added thereto and after adjusting the pH thereof to about 4.5 with an aqueous sodium hydroxide solution with stirring, the mixture was stirred for 30 minutes at 0° C. The crystals thus deposited were washed with water, recovered by filtration, and dried in vacuo at 45° C. to provide 8.3 g of N2 -(1(S)-carbamyl-3-phenylpropyl)-N6 -trifluoroacetyl-L-lysine.

Workup

  1. stirringthe mixture was stirred for 30 minutes at 0° C
  2. washThe crystals thus deposited were washed with water
  3. filtrationrecovered by filtration
  4. customdried in vacuo at 45° C.

Sources & evidence

ORD record
ord-c34b8a51de6a4deb992fd0693b3c999b
Source dataset
uspto-grants-1992_08
Patent number
US05136044

Reaction notes

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