Benzene → Proline benzyl ester

HRID 846317Notes

Reaction equation

HRID 846317 reaction equation
Cl.[NH:2]1[CH2:16][CH2:15][CH2:14][CH:3]1[C:4]([O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:5].C1C=CC=CC=1.O>C(N(CC)CC)C>[NH:2]1[CH2:16][CH2:15][CH2:14][CH:3]1[C:4]([O:6][CH2:7][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:5]

Participants

5

Reactant 3

HCID 241BenzeneHCID 962WaterHCID 308425616652-71-4

Product 1

HCID 99767Proline benzyl esterYield 103%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Conditions

Temperature
20 °C

Procedure

A mixture of 2.4 g of benzyl DL-prolinate hydrochloride, 25 ml of benzene, 5 ml of demineralized water and 1.01 g of triethylamine was stirred at 20° C. for one hour and the decanted organic phase was washed with water, dried and evaporated to dryness under reduced pressure to obtain 2.1 g of benzyl DL prolinate.

Workup

  1. washthe decanted organic phase was washed with water
  2. customdried
  3. customevaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-1a4ef258501848a69bc44ca84ef7100c
Source dataset
uspto-grants-1992_08
Patent number
US05136050

Reaction notes

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