Water → Methyl 2-amino-2-phenylpropanoate

HRID 846318Notes

Reaction equation

HRID 846318 reaction equation
Cl.[NH2:2][C:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:7])[C:4]([OH:6])=[O:5].O.[CH3:15]COCC>C(N(CC)CC)C>[NH2:2][C:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:7])[C:4]([O:6][CH3:15])=[O:5]

Participants

5

Reactant 3

HCID 962WaterHCID 3283Diethyl EtherHCID 200864462-Amino-2-phenylpropanoic acid hydrochloride

Product 1

HCID 14426739Methyl 2-amino-2-phenylpropanoate

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Conditions

Temperature
20 °C

Procedure

A mixture of 4.3 g of methyl DL aminophenylpropanoate hydrochloride, 43 ml of demineralized water, 86 ml of ether and 3 ml of triethylamine was stirred at 20° C. for 10 minutes and the aqueous phase was extracted with ether. The combined ether phases were dried and evaporated to dryness under reduced pressure to obtain 8.3 g of methyl aminophenylpropanoate.

Workup

  1. extractionthe aqueous phase was extracted with ether
  2. dry with materialThe combined ether phases were dried
  3. customevaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-6ca82bfdf8c84548b1347d7d43913e6d
Source dataset
uspto-grants-1992_08
Patent number
US05136050

Reaction notes

Loading…