Trimethylsilyl iodide → 2,4-Diamino-5-(2,3,5-trichlorophenyl)-6-hydroxymethylpyrimidine

HRID 846397Notes

Reaction equation

HRID 846397 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[C:11]([Cl:16])[C:10]=2[Cl:17])=[C:4]([CH2:18][O:19]C)[N:3]=1.C[Si](I)(C)C>S1(CCCC1)(=O)=O>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[C:11]([Cl:16])[C:10]=2[Cl:17])=[C:4]([CH2:18][OH:19])[N:3]=1

Participants

4

Reactant 2

HCID 85247Trimethylsilyl iodideHCID 117391082,4-Diamino-5-(2,3,5-trichlorophenyl)-6-methoxymethylpyrimidine

Product 1

HCID 197050632,4-Diamino-5-(2,3,5-trichlorophenyl)-6-hydroxymethylpyrimidine

Reagents, catalysts & solvents 1

HCID 31347SulfolaneSolvent

Procedure

This compound was made from the compound of Example 2 by reaction with trimethylsilyl iodide in sulpholane at 80° C. mp. 101°-105° C.

Sources & evidence

ORD record
ord-be5085cbe9f54f88b3cc5a6a5f8fa5a9
Source dataset
uspto-grants-1992_08
Patent number
US05136080

Reaction notes

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