Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 846397Generated: October 30, 2026

Trimethylsilyl iodide → 2,4-Diamino-5-(2,3,5-trichlorophenyl)-6-hydroxymethylpyrimidine

https://huagongshe.com/reaction/846397

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrimethylsilyl iodideHCID 85247—
Reactant2,4-Diamino-5-(2,3,5-trichlorophenyl)-6-methoxymethylpyrimidineHCID 11739108—
SolventSulfolaneHCID 31347—
Product2,4-Diamino-5-(2,3,5-trichlorophenyl)-6-hydroxymethylpyrimidineHCID 19705063—

Reaction Steps

This compound was made from the compound of Example 2 by reaction with trimethylsilyl iodide in sulpholane at 80° C. mp. 101°-105° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05136080
Source datasetuspto-grants-1992_08
ORD IDord-be5085cbe9f54f88b3cc5a6a5f8fa5a9
Source noteuspto-grants-1992_08