反应详情

To 10 ml of methylene chloride were added 85 mg (0.31 mmol) of 4-octyloxycarbonyl benzoic acid obtained in Example 32, 95 mg (0.31 mmol) of 4-hydroxy-4'-(2-methyloctanoyl) biphenyl and 20 mg of 4-dimethylamino pyridine, which was added with 70 mg (0.32 mmol) of N,N'-dicyclohexylcarbodiimide. This mixture was reacted by heating under reflux for 4 hours, and the precipitated solid was filtered off. The filtrate was concentrated and isolated by a column chromatography of silica gel to obtain 42 mg (yield 24%) of white (+)-4-(2-methyloctanoyl) biphenyl, 4-octyloxycarbonyl benzoic acid ester having the aforementioned physical and chemical properties.

1. customThis mixture was reacted
2. temperatureby heating
3. temperatureunder reflux for 4 hours
4. filtrationthe precipitated solid was filtered off
5. concentrationThe filtrate was concentrated
6. customisolated by a column chromatography of silica gel