反应详情

To 10 ml of methylene chloride were added 85 mg (0.32 mmol) of 4-nonanoyl benzoic acid obtained in Example 33, 100 mg (0.32 mmol) of (+)-4-hydroxy-4'-(2-methyloctanoyl) biphenyl and 6 mg of 4-dimethylamino pyridine, which was added with 73 mg (0.35 mmol) of N,N'-dicyclohexylcarbodiimide. This mixture was reacted by heating under reflux for 4 hours, and the precipitated solid was filtered off. The filtrate was condensed, isolated by a column chromatography of silica gel and recrystallized with ethyl alcohol to obtain 31 mg (yield 18%) of white 4-(2-methyloctanoyl) biphenyl, 4-nonanoyl benzoic acid ester having the aforementioned physical and chemical properties.

1. customThis mixture was reacted
2. temperatureby heating
3. temperatureunder reflux for 4 hours
4. filtrationthe precipitated solid was filtered off
5. customcondensed
6. customisolated by a column chromatography of silica gel
7. customrecrystallized with ethyl alcohol