Dichloromethane → HCID 19883110, compound

HRID 846589Notes

Reaction equation

HRID 846589 reaction equation
[N:1]1([S:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([O:15]CC3C=CC=CC=3)[N:10]=2)(=[O:8])=[O:7])[CH:5]=[CH:4][CH:3]=[CH:2]1.ClCCl.FC(F)(F)C(O)=O>C1(C)C=CC=CC=1>[N:1]1([S:6]([C:9]2[NH:10][C:11](=[O:15])[CH:12]=[CH:13][CH:14]=2)(=[O:8])=[O:7])[CH:2]=[CH:3][CH:4]=[CH:5]1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 19883101HCID 19883101, compound

Product 1

HCID 19883110HCID 19883110, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The organic washings were combined, dried over anhydrous magnesium sulphate and the solvent evaporated under reduced pressure to give a crude product identified as 2-(pyrrole-1-sulphonyl)-6-benzyloxypyridine. The crude product was treated with dichloromethane (5 cm3) and trifluoroacetic acid (5 cm3) for 24 hours at the ambient temperature. Toluene (10 cm3) was added and the reaction mixture evaporated to dryness under reduced pressure. The crude product was purified by silica chromatography eluting with 30% ethyl acetate in hexane.

Workup

  1. customthe reaction mixture evaporated to dryness under reduced pressure
  2. customThe crude product was purified by silica chromatography
  3. washeluting with 30% ethyl acetate in hexane

Sources & evidence

ORD record
ord-00d8680cdf5046c98cc7756fe0b36006
Source dataset
uspto-grants-1992_08
Patent number
US05137886

Reaction notes

Loading…